| tcsindustryp | Дата: Среда, 04.03.2015, 13:07 | Сообщение # 1 |
| Docetaxel (as generic or underneath the trade name Taxotere) is a clinically well-known anti-mitotic chemotherapy medication (medication which interferes with cell compartmentation). It is acclimated to large for the treatment of heart, ovarian, prostate, and non-small room lung cancer.<> - <> - <> - Docetaxel has an FDA approved call for after treatment of patients who arrange locally advanced, or metastatic mamma or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer chain or relapsed<> - and a European rubber stamp for use in hormone-refractory prostate cancer.<> -
According to a 2005 article in the quarterly Drugs, docetaxel administered as a one-hour infusion every three weeks as a rule over a ten cycle course, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - Respect the effectiveness of docetaxel versus paclitaxel and other taxanes is stilly controversial. Individual more late-model articles have set up "no confirmation that regimens containing docetaxel throw in the towel greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week distribution schedule utilized to be and is at rest considered operative but hip studies are indicating a weekly outline authority be better. A 2010 article in Accepted Clinical Pharmacology states, "weekly application has emerged as the optimal schedule." Docetaxel is marketed worldwide under the honour Taxotere on Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.<citation>
Stamp
Docetaxel is of the chemotherapy pharmaceutical bearing; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an quotation from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Apt to inadequateness of paclitaxel, international scrutiny was carried visible leading to the formulation of docetaxel – an esterified product of 10-deacetyl baccatin III, which is extracted from the renewable and agreeably ready European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl essential dispose on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side gyve instead of the benzyl amide in paclitaxel. The carbon 10 functioning organize revolution causes docetaxel to be more water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a pure authority and is the strenuous ingredient at one's disposal in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing chestnut single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL unproductive pyrogen-free anhydrous polysorbate 80, and a only dosage Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion shopping bag containing 0.9% sodium chloride or 5% glucose after administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and reliable vials are combined to pay a solution of 10 mg/mL and the required portion is drawn from this solution. Vials have an overfill to even up for flowing impoverishment during preparation, foaming, adhesion to vial walls and the uninteresting volume. 20 mg vials may be stored in the service of 24 months in this world 25 °C away from understanding and 80 mg vials respecting 26 months in the same conditions.<> -
Recently Sanofi has got okay because of one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion infusion is simplified during eliminating the before dilution step. The two-vial and one-vial formulations restrict the unaltered dose point, docetaxel trihydrate, and the same excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the unchanging psychedelic nub in the selfsame concentration as the already approved two-vial formulation. The in spite of grade, standing, and sum of polysorbate 80 are closest in the infusion solution of both formulations. The solely difference between these two formulations is the quantity of ethanol.
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